Congenital hyperinsulinism (HI) is the most common cause of severe, persistent hypoglycemia in newborns, infants, and children and is characterized by inappropriate insulin secretion despite low or normal plasma glucose concentrations. Since glucose is the primary energy substrate for the developing brain, delayed diagnosis or inadequate control of hypoglycemia can result in seizures, hypoglycemic brain injury, neurodevelopmental impairment, or death. The consequences of HI are preventable; however, HI is often overlooked, misdiagnosed, or, even when detected, mistreated, with few effective treatment options. We are seeking applications for an innovative study that will further help fill the gaps in research and advocacy identified through the Congenital Hyperinsulinism International (CHI) Collaborative Research Network (CRN) prioritized research agenda. Multi-institution or multi-center collaboration is highly encouraged. Applicants should consider utilizing the HI Global Registry (HIGR) as a data collection tool or data source for the study. HIGR is a global patient-powered congenital hyperinsulinism registry and consists of a series of thirteen surveys covering a patient’s HI experience over their lifetime. Applicants are encouraged to contact CHI to explore how to utilize HIGR. Please contact info@congenitalhi.org if you would like to discuss your proposed project. One $70,000 grant is made possible by the CHI Community and Team CHIbra at the 2026 Million-Dollar Bike Ride.
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